Restart Computer and/or FL Studio. Check that your device is correctly selected in the Audio settings. Try another cable, both the USB for the interface and the XLR. Check driver's and software, someone already mentioned the Focusrite mixer (Focusrite control). Make sure that the correct input is armed in the mixer and that the mixer chanel is This Focusrite Scarlett 2i2 4th Generation is very, very good. It brings together so many of the features that made other interfaces so appealing, like Auto gain, Loopback, external power and vintage modes. Focusrite have wisely done this while tastefully updating and refining the existing things that makes their brand so recognisable like the I have a Focusrite Claret 4Pre TB interface and it works great. However, like most interfaces in its price range, the quality of the pre-amps are not top of the line. That said, they sound good enough for most things, but for vocals I put a pre-amp on the front end to improve the sound quality of vocal recordings. Im currently using the TS to 3.5mm converter to go into a CMOY. But Im worried the TS output at the back of the Scarlett 2i2 still goes through the amp instead of just through the DAC. Because the "monitor" volume knob on the front of the scarlett still control the volume just like the "headphone" volume knob. Like the PreSonus, Focusrite's Scarlett 2i2 features two Mic/Line inputs with phantom power; a larger monitor control knob; and a headphone output with independent level control. On the back, you get a simple pair of 1/4″ outputs for monitors—nothing more, nothing less. Unique to the Scarlett is the Air control, which is switchable on/off The SM57 is a great mic but needs a lot of gain. the 2i2 doesn't have enough available gain for some dynamic mics on soft sources. In addition the noise floor of the 2i2 is quite high when comparing to professional preamps, so cranking the gain is going to give you a noticeable amount of "hiss". Focusrite Scarlett audio interfaces have enabled millions of musicians, songwriters and producers worldwide to record, mix and playback audio. Choose your Scarlett. You've never sounded so good The latest generation mic pre is the best Scarlett has ever heard. Scarlett 2i2 Studio [3rd Gen] Was $229.99 Now $189.99 Scarlett 4i4 [3rd Gen] $199 I'm thinking about getting an audio interface to record my semi-acoustic guitar and I've managed to narrow it down to two options; Focusrite Scarlett 2i2 and Focusrite Scarlett Solo. I don't need to have two guitars plugged in at the same time, so the Solo seemed like my best choice, but then I noticed that it only had one air button. The HD6xx is too heavy a load for the scarlett at louder volumes. This is where the O2 will shine. The O2 was designed to be a strictly neutral amp/dac combo so aside from providing adequate power it is not intended alter the sound in any way. I personally find it adds a touch extra bass punch but that could be my imagination. The Focusrite Scarlett gen3 is only capable of providing +54dB I'd gain at maximum. The Cloudlifter CL-1 provides about 22dB I'd gain (depending on the impedance) With the SM7B into the cloudlifter, you only need about +40dB of additional gain, which means you're keeping the noise floor (hiss) at a manageable level. GsGTqp3.